When tested in mouse ear swelling bioassay, levofloxacin exhibited phototoxicity similar in magnitude to ofloxacin, but less phototoxicity than other quinolones. Severe, and sometimes fatal, hepatotoxicity has been associated with levofloxacin Most cases were not associated with hypersensitivity and should be discontinue immediately if signs and symptoms of hepatitis occur. If patients who are started on oral therapy do not improve within 72 hours, they should be reevaluated and parenteral therapy initiated. 2008 109 Licensed approved for the treating of inhalational anthrax post-exposure in the pediatric population. Levofloxacin undergoes limited metabolism in humans and is primarily excreted as unchanged drug in the urine. Tendinitis or tendon rupture can involve the Achilles, hand, shoulder, or other tendon sites and can occur during or after completion of cases occurring up to several months after fluoroquinolone treatment have been reported. Stop taking levofloxacin and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your levofloxacin uleoo joints.